Pamela J McLean Selected Research

alpha-Synuclein

1/2020	Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.
1/2019	Cellular models of alpha-synuclein toxicity and aggregation.
3/2018	Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.
1/2017	Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein.
1/2017	Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.
1/2017	Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.
1/2016	Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization.
2/2015	Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
1/2015	A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.
7/2014	Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Pamela J McLean Research Topics

Disease

63	Parkinson Disease (Parkinson's Disease) 06/2022 - 05/2002
22	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2004
22	Dementia (Dementias) 01/2020 - 06/2004
17	Synucleinopathies 01/2020 - 04/2008
8	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 08/2005
4	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 12/2015
3	Multiple System Atrophy 01/2019 - 01/2010
3	Proteostasis Deficiencies 01/2016 - 10/2014
2	Rupture 01/2021 - 01/2017
2	Gliosis 01/2020 - 05/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016 - 03/2011
2	Amyloid Plaque 08/2011 - 08/2005
2	Huntington Disease (Huntington's Disease) 12/2006 - 03/2006
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Disease Progression 01/2019
1	Neuroinflammatory Diseases 03/2018
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2015
1	Tauopathies 10/2014
1	Weight Loss (Weight Reduction) 01/2014
1	Parkinsonian Disorders (Parkinsonism) 01/2014
1	Gaucher Disease (Gaucher's Disease) 07/2011
1	Neuroblastoma 04/2006

Drug/Important Bio-Agent (IBA)

38	alpha-SynucleinIBA 01/2020 - 11/2002
27	SynucleinsIBA 01/2022 - 05/2002
21	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2002
3	Amyloid (Amyloid Fibrils)IBA 01/2022 - 08/2011
3	Dopamine (Intropin)FDA LinkGeneric 03/2018 - 09/2009
3	Molecular Chaperones (Chaperone, Molecular)IBA 12/2012 - 08/2004
2	ApolipoproteinsIBA 01/2022 - 01/2020
2	Apolipoprotein E4IBA 01/2022 - 01/2020
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020 - 11/2015
2	Protein AggregatesIBA 01/2017 - 02/2013
2	Peptides (Polypeptides)IBA 01/2017 - 08/2011
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 01/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2011 - 03/2011
2	UbiquitinIBA 10/2011 - 03/2011
1	Cathepsin BIBA 06/2022
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Sirtuin 3IBA 01/2020
1	Apolipoproteins E (ApoE)IBA 01/2020
1	Apolipoprotein E2IBA 01/2020
1	Apolipoprotein E3IBA 01/2020
1	SirtuinsIBA 01/2020
1	Galectin 3 (LGALS3)IBA 01/2017
1	Superoxide Dismutase-1IBA 01/2016
1	Protein Isoforms (Isoforms)IBA 12/2015
1	sarkosylIBA 12/2015
1	Pharmaceutical PreparationsIBA 05/2015
1	Presenilin-1IBA 07/2014
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2014
1	2- fluoro- 6- (tetrahydrofuran- 3- ylamino)- 4- (3,6,6- trimethyl- 4- oxo- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzamideIBA 01/2014
1	Contrast MediaIBA 10/2013
1	Glucosylceramidase (Glucocerebrosidase)IBA 07/2011
1	ElementsIBA 01/2011
1	Tyrosine (L-Tyrosine)FDA Link 11/2009
1	Serine (L-Serine)FDA Link 11/2009
1	Sirtuin 2IBA 07/2007
1	StaurosporineIBA 04/2006
1	Oxidopamine (6 Hydroxydopamine)IBA 04/2006
1	Amyloid beta-PeptidesIBA 08/2005

Therapy/Procedure

3	Therapeutics 05/2015 - 04/2008